Jessica Simpson, Kendra Wilkinson, Khloe Kardashian and More Who Have Weighed In on the Ozempic Craze (2025)

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Why Nikki Glaser Is Fiercely Defending Ozempic

One hot topic everyone in Hollywood still seems to be talking about that isn't Traylor? Oh-oh-oh Ozempic.

Originally marketed for treating Type 2 diabetes, Ozempic—perhaps the most popular of the injectable medications called semaglutide that was FDA-approved in 2017—has become theweight loss trend. And, like many wellness fads in the past, it's sparking debate, especially after the FDA logged a reported shortage of the drug in 2022 due to an increase in demand.

As first reported by Variety, celebrities began taking the insulin drug (and then others like Mounjaro and Wegovy) as a way to lose weight quickly, though many stars suspected of using it have been quick to deny the rumors.

Lizzo, for instance, addressed her weight loss on social media, by writing,"When you finally get ozempic allegations after 5 months of weight training and calorie deficit."

And Kelly Clarkson shared that Ozempic is not her medication of choice. Though, as she said on a May 2024 episode of The Kelly Clarkson Show, she is taking "something that aids in helping break down the sugar—obviously my body doesn't do it right."

photosOprah Winfrey's Weight Loss Journey

Amy Schumer, meanwhile, says she tried Ozempic a couple years ago ("I was one of those people that felt so sick and couldn't play with my son," she admitted) and called out those in Hollywoodwho won't admit that they've done the same.

Not that there aren't some stars who haveshared their experienceswith the drug, including Chelsea Handler,Tracy Morgan, Kendra Wilkinson and Meghan Trainor, who recently revealed both she and husband Daryl Sabara are taking a low dose of Mounjaro.

But other celebs—like Khloe Kardashianand The Real Housewives of Beverly Hills star Kyle Richards—have vehemently denied assumptionsthat they are on Ozempic.

Though Khloe, for one, isn't here to judge.

“Even if people get surgery or [get on] the Ozempic craze, I’m like, ‘Who cares!’” the 40-year-old toldBustle in an interview published Dec. 3. “As long as people feel good about themselves, who am I to judge? I think it’s ridiculous, the judgment on that.” Her biggest gripe, she added,“I’m just mad [Ozempic] wasn’t around 10 years ago.”

A rep for the pharmaceutical company Novo Nordisk, which makes Ozempic, previously told E! News in a statement that Ozempic is "not approved for chronic weight management." The organization said that Ozempic is intended to treat type 2 diabetes, improve blood sugar and minimize risks of major cardiovascular events for adults with the condition.

Here are the stars who have sounded off on the Ozempic craze in Hollywood:

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